Princeton University

Mrl Cambridge Esc

Rob C Oslund

Tom W Muir

Dann LeRoy Parker, Jr

Stefan McCarver

Jung-Min Kee

Jacob Geri

Tamara Reyes-robles

Frances Paola Rodriguez-rivera

David WC Macmillan

James Oakley

Olugbeminiyi O Fadeyi

Tao Wang

Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs.

Phosphohistidine mimetics and antibodies to same

Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these haptens linked to carrier molecules, antibodies thereto and uses of these antibodies, haptens, immunogens and phosphohistidine analogs. The invention is based in part on new pHis analogs that are chemically stable and which have been used as haptens and immunogens to generate specific anti-pHis antibodies that bind with high affinity and specificity.

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Princeton, NJ, United States of America

Rob C Oslund