Kabushiki Kaisha Yakult Honsha

Ritsuo Aiyama

Masato Nagaoka

Shusuke Hashimoto

Ryuta Yamazaki

Takeshi Matsuzaki

Hiroshi Hatano

Tomio Furuta

Yoshikazu Sugimoto

Oh Yoshida

Masako Nakazawa

Yukiko Nishiyama

Teruo Yokokura

Toshiro Sone

Kouji Miyazaki

Katsuyoshi Chiba

Harumi Mizukoshi

Masaaki Watanuki

Katsuhisa Harada

Takashi Makino

Tomoko Hanamizu

Fukiko Nishisaka

Sachiko Matsumoto

Yoriko Deguchi

Kuniko Osada

A breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative or a salt thereof.

BCRP/ABCG2 inhibitor

A composition for retarding skin aging which contains an edible herb medicine or medicines round in Taiwan, in particular a plant extract or extracts having melanin formation-unhibiting, elastase-inhibiting, hyaluronidase-inhibiting, active oxygen-eliminating and/or radical-capturing type antioxidant activities, and a medicinally acceptable base and/or additives for external dermal application. The composition is useful in promoting skin whitening effects, maintaining the tension and elasticity of the skin, facilitating skin moistening and providing the skin with anti-inflammatory and/or anti-allergic properties.

Compositions for retarding skin aging

A camptothecin-containing pharmaceutical composition which contains: (a) camptothecin or a derivative thereof, and (b) one or more compounds selected from among ascorbic acid or a salt thereof, sodium hydrogen sulfite, sodium sulfite, potassium pyrosulfite, sodium erythorbate, sodium thioglycolate, sodium pyrosulfite, and &#x3b1;-thioglycerin. The pharmaceutical composition is useful in that, after storage for a long period of time or under light-irradiation conditions, camptothecin or a derivative thereof contained therein undergoes minimum degradation.

Pharmaceutical compositions containing camptothecins

The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (&#x2014;NHCOCHgroup); a cyano group (&#x2014;CN group); a formyl group (&#x2014;CHO group), &#x2014;COOR(Ris hydrogen or C1-C4 alkyl), &#x2014;O(CH)COOR(n=1&#x2212;7: Ris hydrogen or C1-C4 alkyl), &#x2014;OOCCHCHCOOR(Ris hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., &#x2014;OP(O) (OH)) or a salt thereof, a sulfate group (i.e., &#x2014;OSOH) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

[object Object]

The present invention relates to an &#x3b1;-amylase activity inhibitor, and to food and beverages comprising the &#x3b1;-amylase activity inhibitor. The &#x3b1;-amylase activity inhibitor of the present invention exhibits remarkably excellent &#x3b1;-amylase inhibitory activity as compared with guava extract. Accordingly, food and beverages containing the &#x3b1;-amylase activity inhibitor are diet food and beverages suitable for people of high blood-sugar level or hyderlipidemia.

&#x3b1;-amylase activity inhibitors

A diarylheptanoide derivative of the following formula (1), ##STR1## and a drug composition comprising this compound, such as a 5-lipoxygenase inhibitor, an antiinflammatory agent, and the like. The diarylheptanoide derivative (1) is effective for treating and preventing various inflammatory diseases due to its strong 5-lipoxygenase inhibiting effect.

Diarylheptanoide derivative and pharmaceutical composition comprising

Growing community of inventors

Tokyo, Japan

Ritsuo Aiyama