Osaka University

Medical Biological Laboratories Co., Ltd.

Department of Medical Sciences Ministry of Public Health

Ritsuko Koketsu

Kazuyoshi Ikuta

Motoki Kuhara

Yoshinobu Okuno

Shoji Ideno

Masatoshi Oshita

Masatoshi Momota

Mikihiro Yunoki

Jotika Boon-Long

Kazuhito Fujiyama

Mayo Yasugi

Provided is a human antibody having a neutralization activity against a human influenza virus. More specifically, provided is a human antibody which recognizes a highly conserved region in a human influenza A virus subtype H3N2 or a human influenza B virus and has a neutralization activity against the virus. The human antibody is a human anti-human influenza virus antibody, which has a neutralization activity against a human influenza A virus subtype H3N2 and binds to a hemagglutinin HA1 region of the human influenza A virus subtype H3N2, or which has a neutralization activity against a human influenza B virus, and includes, as a base sequence of a DNA encoding a variable region of the antibody, a sequence set forth in any one of SEQ ID NOS: 5 to 12.

Human anti-human influenza virus antibody

Materials and methods are provided for treating influenza B infections in humans. Anti-human influenza virus monoclonal antibodies and antigen-binding fragments thereof having a neutralization activity against a human influenza B virus are provided. Methods for producing anti-human influenza B virus monoclonal antibodies are also provided. The antibodies and antigen-binding fragments thereof can be effective against a wide range of influenza B viral strains. Methods of inhibiting or treating a human influenza B infection are provided. The anti-influenza B therapeutics can also be used to manufacture medicaments effective against influenza B infections, to detect human influenza B in a human subject, for use in pharmaceutical compositions, and for use in kits for at least one of the prevention, the treatment, and the detection of human influenza B in a human subject.

Human monoclonal antibodies broadly protective against influenza B virus and methods of using the same

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Suita, Japan

Ritsuko Koketsu