Kissei Pharmaceutical Co., Ltd.

Ritsu Suzuki

Takehiro Ishikawa

Yuichiro Kai

Tetsuro Tamai

Hideyuki Muranaka

Hideki Takeuchi

Satoshi Akahane

Tetsuya Nakamura

Junichi Kobayashi

Tatsuhiro Kondo

Tomonaga Ozawa

Kenji Yokoyama

Kosuke Okazaki

Hiroaki Kobayashi

Kiyoshi Kasai

Masahiko Uchida

Yoshihiro Terao

Tetsuji Ozawa

Koji Kamata

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein Rand Rare each hydrogen or lower alkyl; R, R, Rand Rare each hydrogen, halogen, lower alkyl or lower alkoxy; Rand Rare each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; Ris &#x2014;C(O)&#x2014;R, -A-C(O)&#x2014;R, &#x2014;O-A-C(O)&#x2014;Ror a tetrazol-5-yl group, which exhibit potent and selective &#x3b2;3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof

Crystals of a salt of 4'-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3&#x2032;,5&#x2032;-dimethylbiphenyl-4-carboxylic acid. The &#x3b1; type, &#x3b2; type and &#x3b3; type crystals produced by treating hydrochloride of 4&#x2032;-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethylamino]ethoxy}-3-isopropyl-3&#x2032;,5&#x2032;-dimethylbiphenyl-4-carboxylic acid with specified solvents, which can be discriminated by the characteristic diffraction peaks of powder X-ray diffractometry and the like.

Polymorphic crystal of 4'-{2-[ (1S, 2R)&#x2014;2-  hydroxy-2- (4-hydroxyphenyl)-1-methylethylamino]ethoxy} - 3 - isopropyl-3&#x2032;, 5&#x2032; -dimethylbiphenyl- 4 - carboxylic acid hydrochloride

The present invention relates to a 5-amidino-N-(2-aminophenethyl)-2-hydroxybenzenesulfonamide derivative represented by the general formula:wherein Ris a hydrogen atom or a lower alkyl group;

5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide derivative, medical composition containing the same, pharmaceutical use thereof and intermediate therefor

Growing community of inventors

Toyoshina-machi, Japan

Ritsu Suzuki