Nicox Ophthalmics, Inc.

Integral Biosystems LLC

Ritesh Vasudevan Thekkedath

Shikha P Barman

Thomas Cavanagh

Tian Hao

Thomas Bovard Leland

Koushik Barman

Kevin L Ward

Anne-Marie Cromwick

The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).

Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof

A liquid crystalline drug delivery system for ocular administration. The drug delivery system, which is mucoadhesive, biocompatible, non-irritating, and tissue permeable, contains nanoparticles stably dispersed in an aqueous solution and can be formulated for sustained release. Also provided are methods for producing the drug delivery system and methods for treating ocular disorders by administering it to a subject.

Membrane-adherent self-assembled systems for treatment of ocular disorders

Membrane-adherent self-assembled system for treatment of ocular disorders

The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).

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Boston, MA, United States of America

Ritesh Vasudevan Thekkedath