Egis Gyogyszergyar Nyrt

Rita Kapillerné Dezsöfi

Gyula Simig

Tibor Mezei

József Barkóczy

Balázs Volk

György Lévay

Katalin Pallagi

Krisztina Móricz

István Gacsályi

Gábor Gigler

András Egyed

László Gábor Hársing

Csilla Leveleki

Nóra Sziray

Gábor Szénási

Gábor Szenasi

Endréné Flórian

The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favorable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system. 

Piperazine derivatives of alkyl oxindoles

The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein Rstands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; Rrepresents hydrogen or halogen; Rdenotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); Rstands for alkyl having 1-7 carbon atom(s); Rrepresents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R, Rand Reach stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or Rand Rtogether represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system. 

Piperazine derivatives of dialkyl oxindoles

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Budapest, Hungary

Rita Kapillerné Dezsöfi