Sigea S.r.l.

Bmg Pharma S.p.a.

Siega S.r.l.

Rita Gianni

Luca Stucchi

Marco Bosco

Fabrizio Picotti

Alessandra Sechi

Antonia Trevisan

The present invention relates to a process for the preparation of pharmaceutical, injectable or ophthalmic grade hyaluronic acid, or a salt thereof, for use in the dermocosmetic or pharmaceutical field or in medical devices, which comprises dissolution of hyaluronic acid or a salt thereof in organic solvent, a heat cycle, and recovery of the product by precipitation and successive washes in organic solvents.

Process for the purification of hyaluronic acid salt, conducted in organic solvent

The present invention relates to a process for the preparation of hyaluronic acid butyrate, or a salt thereof, acceptable for pharmaceutical or cosmetic use or as a medical device, comprising reacting hyaluronic acid, salified with sodium or another alkali metal, in aqueous solution with butyryl-imidazolide in the presence of sodium carbonate. The present invention also relates to pharmaceutical formulations, cosmetic formulations or medical devices containing the hyaluronic acid sodium salt (HA) butyric esters produced by said process.

Process in water for the preparation of butyric esters of hyaluronic acid sodium salt

Non-crosslinked derivatives of oligo/polysaccharides of formula 

Polysaccharides derivatised with citric acid

Disclosed are acid polysaccharides characterized by the concomitant presence of alcohol groups esterified with butyric and formic acids.

Mixed butyric-formic esters of acid polysaccharides, and their preparation and use as skin cosmetics

Acid polysaccharides characterized by the concomitant presence of partial esters with non-polysaccharide carboxylic acids and esters between the acid groups of the initial polysaccharide and the alcohol groups of the repetitive units, with the formation of crosslinking among the polysaccharide chains.

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Monrupino, Italy

Rita Gianni