The University of Texas System

Rita Ghosh

Thomas J Slaga

Huiyun Liang

Anna Mancha Ramirez

Roble Bedolla

Izhar Singh Batth

Ian M Thompson, Jr

Addanki Pratap Kumar

Daniel Glade

Certain embodiments are directed to modified glucocorticoid compounds having one or both of (i) a substitution of a halogen for the 11 hydroxy and/or (ii) reduction of the bond between carbon 4 and carbon 5 of the A ring.

Modified glucocorticoids

Certain embodiments are directed to methods of identifying a subject having a higher risk of prostate cancer recurrence. The methods can include the step of measuring levels of one or more of FLIP, transcription factor Sp1, and transcription factor Sp3 in a prostate sample from the subject, wherein elevated levels of FLIP, transcription factor Sp1, and transcription factor Sp3 identify a subject as high risk for prostate cancer recurrence.

Methods for assessing cancer recurrence

Growing community of inventors

San Antonio, TX, United States of America

Rita Ghosh