Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Risa Tsuruta

Masato Takahashi

Hiroki Urabe

Tetsuya Yabuuchi

Hajime Takashima

Yusuke Oka

Hironori Kotsubo

Fumito Uneuchi

Muneo Shoji

Yasuko Kawaguchi

Yoichiro Suga

Toru Yamaguchi

Naoya Ono

Fumihito Ushiyama

Tetsuya Tanikawa

Yasunobu Ushiki

Yasuhiro Tsutsui

Noritomo Fujino

Keiko Yamamoto

Ayumu Mori

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. 

Hydroxamic acid derivative

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: 

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

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Toshima-ku, Japan

Risa Tsuruta