Pharmacia & Upjohn Company

Elan Pharmaceuticals, Inc.

Other

Riqiang Yan

Mark E Gurney

Robert L Heinrikson

Michael Jerome Bienkowski

Luis A Parodi

Alfredo Giuseppe Tomasselli

Thomas L Emmons

Michael J Bienkowaki

The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &#x3b2;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.

Substrates and assays for &#x3b2;-secretase

The present invention provides the enzyme and enzymatic procedures for cleaving the &#x3b2; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.

Alzheimer's disease secretase

The present invention provides the enzyme and enzymatic procedures for cleaving the &#x3b2; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

Alzheimer's disease secretase, APP substrates therefor, and uses therefor

Substrates and assays for &#x3b2;-secretase activity

The present invention provides the enzyme and enzymatic procedures for cleaving the &#x3b2; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

Alzheimer's disease secretase, APP substrates therefor, and uses thereof

The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.

The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.

The present invention provides methods of reducing cellular production of amyloid beta (A&bgr;) from amyloid precursor protein (APP) by reducing Asp2 transcription or translation in cells.

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Kalamazoo, MI, United States of America

Riqiang Yan