University of Texas System

Other

Noninvasix, Inc.

Rinat O Esenaliev

Donald S Prough

Irene Y Petrov

Yuriy Petrov

Massoud Motamedi

George Saade

Gayle L Olson

Alexander A Oraevsky

Tommy Gene Cooper

Maria-Adelaide Micci

C Joan Richardson

Nicholas Alexander Kotov

Steven Louis Jacques

Michael P Kinsky

Alexander A Karabutov

James P Wicksted

Rovnat Babazade

Donald D Prough

Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

Nanopulse light therapy

Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided.

Ultrasound-guided optoacoustic monitoring of oxygen saturation

In one embodiment, a system for locating a tip of a catheter that has been inserted into a patient includes an implantable catheter having a distal tip, a pulsed light source that is co-located with the distal tip of the implantable catheter, the pulsed light source being configured to emit pulses of light into surrounding patient tissue, an optoacoustic sensor configured to be applied so a skin surface of the patient at a position proximate to the pulsed light source and to sense optoacoustic waves generated when the pulses of light are absorbed by the surrounding patient tissue, and an optoacoustic console configured to receive optoacoustic wave signals from the optoacoustic sensor and to display an indication of the optoacoustic wave signals to a medical professional to provide an indication of the location of the pulsed light source and, therefore, the distal tip of the implantable catheter.

Systems and methods for locating an inserted catheter tip

Disclosed herein are systems and methods for monitoring one or more of cerebral oxygenation and total hemoglobin concentration that can be used to perform accurate, noninvasive measurement of cerebral venous blood oxygen saturation (oxygenation) in neonatal patients. A neonatal cerebral oxygenation detection apparatus comprises a wearable support having a light emitter and an acoustic sensor coupled thereto. The wearable support can be secured onto a head of an infant, and the light emitter can be configured to emit a light toward a superior sagittal sinus of the infant's head. The acoustic sensor can be configured to detect acoustic pressure generated by blood in the superior sagittal sinus when the superior sagittal sinus blood absorbs the light. Cerebral oxygenation and/or total hemoglobin concentration can be determined based on the acoustic pressure detected by the acoustic detector.

Systems and methods for measuring neonatal cerebral oxygenation

Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

Systems and methods for measuring oxygenation or hemoglobin concentration

Methods are disclosed for treating cell components, cells, organelles, organs, and/or tissues with acoustic energy, electromagnetic energy, static or alternating electric fields, and/or static or alternating magnetic fields in the presence or absence of exogenous particulate agents for therapeutic applications.

Noninvasive therapies in the treatment of pathogenic infections

Systems and methods for measuring oxygenation

Medical apparatus are disclosed for optoacoustic monitoring of an indwelling unit of the apparatus, where the indwelling unit includes one or more optical components capable of directing pulsed light into an overlying tissue. The apparatus also include one or more acoustic components in contact with an exterior surface of the tissue to detect induced pressure waves producing an acoustic output analyzed with an optoacoustic unit to monitor and confirm proper placement of the indwelling unit. Methods for using the apparatus are also disclosed.

Methods and apparatus for optoacoustic guidance and confirmation of placement of indwelling medical apparatus

New wearable systems for noninvasive glucose sensing include an ultrasound generator, an ultrasound detector and a feedback unit. Methods for noninvasive glucose sensing using a wearable device include measuring a thickness (geometrical and/or optical) of a target tissue or a time of flight of ultrasound or optical pulses in the target tissue and determining a glucose value from the thickness of the target tissue or the time of flight in the target tissue in accordance with a target tissue thickness (geometrical and/or optical) or time of flight versus glucose calibration curve.

Wearable, noninvasive glucose sensing methods and systems

Noninvasive therapies in the presence of exogenous particulate agents

Noninvasive therapies in the absence or presence of exogenous particulate agents

Systems and methods for measuring fetal cerebral oxygenation

Growing community of inventors

League City, TX, United States of America

Rinat O Esenaliev