Fidia Farmaceutici S.p.a.

Euticals Spa

Rinaldo Marini Bettolo

Luisa Maria Migneco

Gilda De Luca

Mario Brufani

Barbara Garofalo

Adriana Caterina Maggi

Luigi Filocamo

Paolo Maria Farina

Gillian Ashcroft

Francesca Ceccacci

Roberta Joudioux

The invention relates to 17&#x3b1;-(5-hydroxy-C-hydrocarbyl)-1,3,5(10)-estratrien-3,17&#x3b2;-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17&#x3b1;-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5'-esters and 3,5&#x2032;-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-&#x2032; or 3,5&#x2032;-esterif&#xca;cation.

17-alpha-substituted derivatives of estradiol with wound-healing activity

The present invention relates to water-soluble taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives, and in particular to paclitaxel and docetaxel, useful for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenosis. The invention also relates to the process for preparing taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivates by direct synthesis between molecules of hyaluronic acid and of taxane or by indirect synthesis by the introduction of a spacer between the hyaluronic acid derivative and the taxane.

Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives

The present invention relates to water-soluble taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives, and in particular to paclitaxel and docetaxel, useful for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenoisis. The invention also relates to the process for preparing taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives by direct synthesis between molecules of hyaluronic acid and of taxane or by indirect synthesis by the introduction of a spacer between the hyaluronic acid or hyaluronic acid derivative and the taxane.

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Rome, Italy

Rinaldo Marini Bettolo