The University of Chicago

Other

Northwestern University

University of Strathclyde

University of Leeds

University of Sheffield

Institute for Systems Biology

Infectious Disease Research Institute

Government of the United States

J. Craig Venter Institute

Paxvax, Inc.

Apicomplexan Therapeutics, LLC

Emergent Travel Health Inc.

Rima McLeod

Kamal El Bissati

Craig Roberts

Ernest J Mui

Richard B Silverman

Leroy E Hood

Hoang V Le

Dustin D Hawker

Yong Zhou

Mark Hickman

Ying Zhou

Taek-Kyun Kim

Colin W G Fishwick

QiGui Li

Martin McPhillie

Hernan Alejandro Lorenzi

Steven G Reed

Jonathan B Rothbard

Kai Hua Wang

Piotr Gornicki

Hong M Moulton

Jeffery L Alexander

Fiona Roberts

Ellen Zuther

Tze Guan Tan

Kai Wang

Benjamin Samuel

Jeff Alexander

William H Witola

Steve Reed

Peter Burkhard

Hua Cong

Darrel Irvine

Ron Weiss

Bo Shiun Lai

Yuan Zhang

William Witola

Mariane Melo

Jon D Moulton

Jennifer J Johnson

David Ferguson

Michael Kirisits

Russell Lyons

Doug Mack

Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limitinginfection.

Toxoplasma gondii vaccines and their use

Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases

Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Disclosed are methods, compounds, and compositions for treating infection by an Apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the Apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection byand toxoplasmosis and for treating infection byand malaria. The compounds disclosed herein are observed to selectively inactivateornithine aminotransferase (TgOAT) relative to human OAT and relative to human &#x3b3;-aminobutyric aminotransferase (GABA-AT).

Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria

Inactivators ofornithine aminotransferase for treating toxoplasmosis and malaria

Vaccines are disclosed against parasites. The vaccines include peptides in an immunological composition. In particular, the parasite is

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Pharmaceutical formulations of antisense peptide-conjugated phosphorodiamidate morpholino olgomers and methods of use for treatment of apicomplexan infections are disclosed. The invention is particularly directed to treatment ofinfections.

Conjugate constructs, delivery, and use for treatment of disease

This invention relates uses of chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on chorismate synthase and its inhibitors.

Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

Growing community of inventors

Chicago, IL, United States of America

Rima McLeod