Evonik Roehm Gmbh

Evonik Corporation

Evonik Operations Gmbh

Rima Jaber

Norbert Windhab

Kevin Burton

Andrea Engel

Silko Grimm

Axel Schroeder

Tom Tice

David Fecher

Min Yang

Maria Camilla Operti

Axel Schroder

Axel SCHRÖDER

A process can be used for preparing nanoparticles containing at least one bio-resorbable polyester. The nanoparticles are in the form of a powder with a Z-Average particle size Din the range of 1 to 450 nm, and with a polydispersity index PDI in the range of 0.01 to 0.5. The process involves emulsion-solvent extraction or emulsion-solvent evaporation, and application of ultrasonic sound.

Process for preparing nanoparticles in the form of a powder comprising a bio-resorbable polyester

An injection solution can be used in a pharmaceutical dosage formulation. The injection solution includes an organic solvent, a copolymer, which is a poly(lactide-co-glycolide) dissolved in the organic solvent, and a pharmaceutical active ingredient, which is a non-nucleoside inhibitor of the HIV reverse transcriptase or of the HIV integrase, and which contains aromatic and heterocyclic aromatic or aromatic and heterocyclic aromatic and aliphatic heterocyclic groups, where a content of the pharmaceutical active ingredient is from about 8 to about 25% by weight of the copolymer solution.

Injection solution comprising a non-nucleoside reverse-transcriptase inhibitor and poly(lactide-co-glycolide)

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Rima Jaber