University of Michigan

Other

Wayne State University

Riley S Rees

Belinda Adamson

Cynthia Marcelo

Warren Garner

Cynthia Zuccaro

Thomas E Taddonio

Robert Gilmont

Lenore Rhodes

Beverly Marchant

William J Lindblad

Jiyoun Kim

Daniel Remick

The present invention relates to devices, systems and methods for treating tumors. In particular, the present invention relates to enclosures housing cell-coated supports for promoting regression of tumors, such as cancerous tumors, papillomas, and warts. In preferred embodiments, the present invention provides methods of promoting tumor regression employing enclosures secreting therapeutic proteins.

Enclosures housing cell-coated supports for treating tumors

Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), involving the use of keratinocytes are described. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter.

Manufacturing therapeutic enclosures

Therapeutic enclosures

Methods and compositions for the treatment of wounds

System for the treatment of wounds

Devices and methods for enhancing the healing of wounds, especially chronic wounds (e.g., diabetic wounds), are provided involving the use of keratinocytes. Keratinocytes are grown on a transplantable solid support (e.g., collagen-coated beads), and the keratinocyte-coated solid support is placed in an enclosure. The enclosure, in turn, is placed in the wound for use as an interactive wound healing promoter. After the enclosure is placed in a wound, the wound may be covered with a dressing. The enclosure is degradable or non-degradable, and is constructed from a membrane or a porous polyester mesh material having pores that are either too small or large enough for keratinocytes to cross. A means may be attached to the enclosure to enable removing the enclosure from a wound.

Wound treatment with keratinocytes on a solid support enclosed in a

Growing community of inventors

Ann Arbor, MI, United States of America

Riley S Rees