B.G. Negev Technologies and Applications Ltd.

Other

Tel Aviv University

Cincinnati Children's Hospital Medical Center

Ben-gurion University of the Negev Research and Development Authority

Riki Goldbart

Joseph Kost

Tamar Traitel

Dan Peer

Jeffrey A Whitsett

Nitzan Marelly

Assaf Rudich

Etili Hollander

Shani Attias

Eliz Lewis Amar

Rinat Lifshiz

Paul Scot Kingma

Giora Enden

Nitsa Buaron

A controlled release system includes surfactant protein D (SPD) and a carrier suitable for controlled release that can be polylactic-co-glycolic acid (PLGA). The system can be in the form of a nanoparticle. A pharmaceutical composition includes the system and a pharmaceutically acceptable carrier. Methods of treatment of a disease, disorder or condition associated with a decreased level of SPD in a subject, or for pulmonary delivery of SPD, include administering the pharmaceutical composition to a subject in need of such treatment.

Controlled release system for pulmonary delivery of surfactant protein D

The present invention provides a complex comprising at least one phosphoinositide and at least one positively charged modified polysaccharide, pharmaceutical compositions comprising the complex, methods for treatment of a disease, disorder or condition associated with impaired phosphoinositide-mediated signaling comprising administering the complex to an subject in need, and methods for delivery of a phosphoinositide into cells, comprising contacting the cells with the complex of the invention.

Cationic polysaccharides for delivery of phosphoinositides to cells for therapeutic purpose

A complex includes RNA and a positively charged modified polysaccharide selected from starch, amylose, amylopectin, galactan, chitosan, or dextrin. The complex can be formed into a pharmaceutical composition. The complex can be used in methods for RNA transfection, gene therapy and treatment of a disease, disorder or condition. The positively charged modified polysaccharide can be used in connection with RNA transfection into cells.

Positively charged polysaccharides for RNA transfection

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Lehavim, Israel

Riki Goldbart