Everest Biosciences, Inc.

Spago Nanomedical Ab

Oncorel Ab

Rikard Larsson

Olov Sterner

Martin Johansson

Jenny Persson

Oskar Axelsson

Andreas Gram

The present disclosure relates to a method of immobilizing a phenolic compound having a M≥500 g/mol, wherein the method comprises the steps of ionizing the phenolic compound by subjecting it to a base; and contacting, under agitation, the ionized phenolic compound with a cross-linked resin comprising the functionality of —C(═O)—CHXCHR, wherein X is chosen from the group consisting of Br, Cl, I, CN, OMs, OTs, or OTf, and R is H, CHor an branched or unbranched alkyl having 1 to 8 carbon atoms, in the presence of a base and a solvent. The present disclosure also relates to a method of removing phenolic compounds having a M≥500 g/mol from a composition comprising compounds having at least one alkoxy silane group. The present disclosure also relates to the use of a method according to the present disclosure as well as to a product, from which at least one phenolic compound having a M≥500 g/mol has been removed by a method according to the present disclosure.

Immobilization of phenolic compounds

The disclosure describes compounds of formula I, wherein the wedged bonds, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier. 

Indolyl-substituted pyrazino[1,2-b]isoquinolines for cancer treatment

Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer

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Tagarp, Sweden

Rikard Larsson