Arexis Ab

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Hansa Medical Ab

Other

Astra Aktiebolag

Resistentia Pharmaceuticals Ab

Vacara Ab

Holmdahl, Rikard

Rikard Holmdahl

Harald Burkhardt

Jan Ake Engstroem

Jan Kihlberg

Lars Björck

Mikael Vestberg

Kutty Selva Nandakumar

Peter Olofsson

Balik Dzhambazov

Ralph Lennart Brattsand

Lars Bjorck

Mattias Collin

Maria Allhorn

Lars T Hellman

Lars Pettersson

Theo Rispens

Bingze Xu

Changrong Ge

Marjana Loncar

Liselotte Jansson

Jan Ake Engstrom

Oonagh Shannon

Arne Olsén

Nadine Schneider

Sylvia Cienciala

Arne Olsen

The invention relates a compound comprising (a) a peptide and (b) a carrier, wherein said peptide having at least the motif X-X-X-X-X-X-X, wherein at least one amino acid residue X is glycosylated, said peptide being linked to the peptide binding protein and said carrier comprises at least a MHC binding motif being linked to said peptide as well as pharmaceutical compositions comprising said compound and the use of said compound or pharmaceutical composition for the treatment of a disease, such as an inflammatory joint disease. The subject matter of the application is exemplified with peptides derived from type II collagen such as peptides having at least the sequence AGFKGEA, or IAGFKGEQPKG, or the peptide AAAKAAA. Preferably a hydroxylysine in the peptides are glycosylated.

Compound comprising an autoantigenic peptide and a carrier with a MHC binding motif

The present disclosure concerns antibodies and antibody fragments binding to citrullinated proteins (ACPA), and their use in prevention and treatment of autoimmune diseases, specifically rheumatoid arthritis (RA).

Antibodies to citrullinated proteins

Novel complexes of peptides from human collagen type II and types of MHC class II associated with rheumatoid arthritis are provided. There is also provided novel therapies and methods for diagnosis of rheumatoid arthritis.

Complexes of types of MHC class II that bind to collagen type II peptides and their use on diagnosis and treatment

The invention provides use of an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.

Use of the endoglycosidase endos for treating immunoglobulin G mediated diseases

The invention provides use of an IdeS polypeptide, or a polynucleotide encoding an IdeS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.

Method of treating or preventing a disease or condition mediated by pathogenic IgG antibodies

The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions that are accompanied by an NADPH oxidase deficiency, and methods and materials involved in identifying agonists and antagonists of NADPH oxidase activity.

Autoimmune conditions and NADPH oxidase defects

The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5. For example, the methods and materials described herein can be used to reduce the effects of C5within a mammal by reducing the amount of total and receptor bound C5in the mammal.

Methods and materials for treating inflammatory conditions

The invention provides methods and materials related to treating and diagnosing autoimmune conditions. Specifically, the invention provides polypeptide compositions, nucleic acids, substantially pure polypeptides, host cells, and methods for identifying a mammal with an autoimmune condition, treating a mammal with an autoimmune condition, and enhancing tolerance in a mammal with an autoimmune condition.

Triple polypeptide complexes

Estrogens

Growing community of inventors

Lund, Sweden

Rikard Holmdahl