Mitsubishi Tanabe Pharma Corporation

Rikako Kono

Masami Takahashi

Tsutomu Miyake

Hidetoshi Asai

Toshihiro Hosaka

Hiroyuki Kobayashi

Takeshi Yamanaka

Yasunori Moritani

Kiyomi Ohba

Mitsuya Hongu

Taketoshi Ishii

Mari Kusama

Toshihiko Kashiwagi

Shuntarou Kohnomi

A large conductance calcium-activated K channel opener comprising as an active ingredient a nitrogen-containing 5-membered heterocyclic compound represented by the following formula (I): 

Large conductance calcium-activated K channel opener

The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, Rrepresents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein Rand Rare the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., Rrepresents hydrogen atom, etc., Z represents oxygen atom or a group represented by &#x2014;N(R)&#x2014;, Rrepresents hydrogen atom or an alkyl group, etc., Rrepresents hydrogen atom or an alkyl group, etc., or a pharmaceutically acceptable salt thereof. 

Piperidine compounds

There are disclosed a large conductance calcium-activated K channel opener comprising a compound of the formula (I): 

The present invention relates to a piperidine compound represented by the formula [I]:  

Piperidine compound and process for preparing the same

Growing community of inventors

Saitama, Japan

Rikako Kono