Roche Diagnostics Operations, Inc.

Roche Diagnostics Hematology, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Rijk Edwin Oosterbroek

Emad Sarofim

Christoph Boehm

Claudio Cherubini

Stephen Conroy

Susanne Wuerl

Brigitte Niederberger

Ertan Ergezen

Carlo S Effenhauser

Manfred Augstein

Andreas Drechsler

Goran Savatic

Michael Glauser

Stephan Korner

Mario Curcio

Geza Burghardt

Oliver Gutmann

Heiko Schwertner

Roger Sandoz

Daniel Müller

The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.

Sample processing systems and methods

A cuvette comprising a body having an upper part comprising an upper open top portion and upper walls forming four upper inner edges and an upper open bottom portion with a first substantially rectangular cross-section in a plane A-A; and a lower measurement chamber comprising a lower closed bottom portion and lower walls forming four lower inner edges and a lower open top portion with a second substantially rectangular cross-section in a plane B-B smaller than the first cross-section in the plane A-A. An abrupt transition zone is positioned between the plane A-A and the plane B-B comprising four transition inner edges connecting the four lower inner edges to the upper open bottom portion. At least in the plane B-B the lower inner edges comprise fillets having a first radius (R). At least in the plane A-A the upper inner edges comprise fillets having a second radius (R) being larger than (R).

Cuvette for photometric measurement of small liquid volumes

Centrifugal force based microfluidic systems for the automated analysis of fluids involving the use of magnetically responsive particles and methods thereof are disclosed. A magnet is fixed to a supporting device of the system in correspondence to a retention zone of the system so as to rotate therewith and to generate a magnetic field which magnetically manipulates the magnetically responsive particles contained in a reaction chamber of the system.

Centrifugal force based microfluidic system and method for the automated analysis of samples

Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.

Method for carrying out reactions in an analytical device

A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

Microfluidic element for analyzing a liquid sample

Growing community of inventors

Cham, Switzerland

Rijk Edwin Oosterbroek