Kikkoman Corporation

Daiichi Pure Chemicals Co., Ltd.

Riichiro Uchida

Takeharu Nakahara

Hitomi Aota

Yoichi Hanada

Yoshikazu Endo

Ayako Nasu

Shigeki Tanizawa

Nobuyuki Yamaji

Seiichi Hara

Shoichi Tokutake

Koichiro Tobe

Yukihiko Iwai

Yoshinori Motoyama

Kenji Hosoi

Takuya Sato

Takao Someya

Katsutoshi Sugimoto

Hiroki Ono

The present invention provides soy sauce that comprises significant amounts of peptides, and, in particular, hypotensive peptide Gly-Tyr and hypotensive peptide Ser-Tyr, exhibiting a high degree of angiotensin-I-converting enzyme-inhibitory activity and has hypotensive effects while containing no hypotensive agent. Target soy sauce is obtained by mixing soy sauce koji having protease activity of 20 to 300 U/g koji with an aqueous common salt solution and subjecting the mixture to heated digestion, followed by compression filtration. Target soy sauce with a good flavor is obtained by adding soy sauce lactic acid bacteria and soy sauce yeast cells to the moromi mash after heated digestion, and subjecting the resultant to fermentation and maturation, followed by compression filtration.

Soy sauce having hypotensive effects and method for producing the same

To provide ACE inhibitory peptides which can effectively inhibit ACE by a small amount of ingestion and have no fear of causing side effects and which can be orally ingested easily during daily life by persons having high blood pressure, and compositions comprising the peptides. The peptides represented by the following structural formulae (1) to (9), and salts thereof are provided. (1) Asp-Arg-Pro, (2) Asn-Trp, (3) Val-Gly-Leu, (4) Ile-Gly-Val, (5) Gly-Val-Pro, (6) Ile-Pro-Tyr, (7) pyroGlu-Pro, (8) Tyr-Thr, (9) Pro-Trp.

Angiotensin converting enzyme inhibitory peptide

A fermented seasoning which does not have the bitterness specific to peptides and can be easily ingested orally, in spite of containing large amount of peptides is provided. Namely, a fermented seasoning obtained by adding salt water to anculture or a mixture of theculture with a plant-derived protein material and by controlling the leucine aminopeptidase-I activity in the moromi to be 1.0 U/ml or less, and also controlling the leucine aminopeptidase-II activity in the moromi to be 0.5 U/ml or less, within 10 days after the preparation.

Peptide-containing seasoning

The present invention provides a substance which strongly inhibits human &#x3b1;-amylase and is effective for the prevention and treatment of hyperglycemia, for example, diabetes and the diseases caused thereby, and an &#x3b1;-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia containing the said substance as active principle. Maltoligosaccharide derivatives represented by the following formula:(wherein n is an integer of 0 to 2; m is an integer of 0 to 2; and X represents a hydrogen atom or a hydrophobic group) or their hydrates or physiologically acceptable salts are provided, and they are contained as active principle to prepare an &#x3b1;-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia such as diabetes.

Malto-oligosaccharide derivatives and use thereof

Malto-oligosaccharide derivatives and uses thereof

A process for differentially determining .alpha.-amylase isoenzyme activities by the inhibitor method, in which 6.sup.3 -deoxymaltotriose (DOG3) represented by the formula ##STR1## is used as an inhibitor.

Differential determination process of .alpha.-amylase isoenzyme

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Noda, Japan

Riichiro Uchida