Cell Pathways

University of Arizona

Osi Pharmaceuticals, Inc.

Other

Michigan State University

Midway Pharmaceuticals, Inc

Fgn, Inc.

Rifat Pamukcu

Gary A Piazza

Gerhard J Sperl

Klaus Brendel

Paul Gross

Kerstin B Menander

Ulrich Ixkes

Xiaojing Michael Wang

W Joseph Thompson

Ewa Skopinska-Rozewska

Han Li

Laura Rae McCabe

Li Liu

Joseph M Lobacki

Bing Zhu

The present invention relates to the administration of compositions comprising polyethylene glycol, for improving the general gastrointestinal health of an animal increasing growth performance and treating osteopenia, osteoporosis and other bone disorders.

Managing osteoporosis with HMW PEG

A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.

Method of inhibiting neoplastic cells with indole derivatives

This invention provides a method for diagnosing a patient with neoplasia.

Diagnostic methods for neoplasia

This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic platinum coordination complex.

Method for treating a patient with neoplasia by treatment with a platinum coordination complex

Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.

Substituted condensation products of N-benzyl-3-indenylacentamides with heterocyclic aldehydes for neoplasia

Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.

Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives

This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic vinca alkaloid derivative.

Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative

This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.

Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds

&lsqb;4,5&rsqb;-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia

A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to isoquinoline derivatives.

Method of inhibiting neoplastic cells with isoquinoline derivatives

Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.

Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives

This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.

Method for treating a patient with neoplasia by treatment with a paclitaxel derivative

1,3,6,-Trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia

A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.

Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones

Benzothienopyrimidine derivatives for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and specifically for arresting and treating neoplasia, including precancerous and cancerous lesions.

Growing community of inventors

Spring House, PA, United States of America

Rifat Pamukcu