Kyowa Hakko Kogyo Co., Ltd.

Rieko Nakatsu

Yutaka Kanda

Shinji Nara

Shiro Akinaga

Timothy A Grese

Yukimasa Shiotsu

Mitsunobu Hara

Douglas Linn Gernert

Shiro Soga

Takayuki Nakashima

Yushi Kitamura

Jiro Kajita

Hiroshi Nakagawa

Jun Eishima

(wherein n is an integer of 0 to 10; Rrepresents substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted lower alkoxycarbonyl, substituted or unsubstituted heterocyclic-alkyl, substituted or unsubstituted aryl, &#x2014;CONRR, &#x2014;NRR, etc.; Rrepresents substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; Rand Rmay be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, etc.; Rand Rmay be the same or different, each represent a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, etc.) Provided are an Hsp90 family protein inhibitor comprising, as an active ingredient, a benzene derivative of formula (I) or a prodrug thereof or a pharmaceutically-acceptable salt thereof, etc.

Hsp90 family protein inhibitors

This invention relates to substituted piperidine derivatives having at least one six-membered ring substituent. The piperidine derivatives exhibit antitumor activity and are useful as pharmaceuticals such as an antitumor agent.

Piperidine derivatives

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Yokohama, Japan

Rieko Nakatsu