Green Tech Co., Ltd.

The Doshisha

National Center for Geriatrics and Gerontology

Rie Tokizane

Hachiro Sugimoto

Yoshikazu Inoue

Michiaki Okuda

Shinichi Nakayama

Yoko Sakata

Yuki Fujita

Tetsuo Ota

Yasuo Ihara

Tomohiro Miyasaka

Yohei Oe

Akihiko Takashima

Yuki Shinzaki

Yoshiyuki Soeda

A tau aggregation inhibitor can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof. The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

Tau aggregation inhibitor

Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): ora salt thereof.

Pyrazole derivative

Growing community of inventors

Hyogo, Japan

Rie Tokizane