Kyorin Pharmaceutical Co., Ltd.

Nisshin Pharma Inc.

Rie Shibayama

Masashi Suzuki

Koji Kawamura

Hitoshi Inoue

Takuya Kishimoto

Ryuuta Fukutomi

Kouichirou Hagihara

Kazuko Kojima

There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III):  The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid &#x3bc; antagonistic activity and are useful for the treatment or prevention of side effects which are caused by &#x3bc; receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same

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Iruma-gun, Japan

Rie Shibayama