Mitsubishi Kasei Corporation

Rie Matsui

Kazuhiro Takahashi

Yutaka Teranishi

Naomi Kitamura

Yoshimi Takai

Jun Kondo

Yasushi Matsui

Keiji Miyazawa

Shigetada Nakanishi

Hirohito Tsubouchi

Daiji Naka

Yoshiko Yoshiyama

Yasushi Daikuhara

Michiru Kamizono

Tatsurou Shibui

Takehisa Ishii

According to the present invention, there are provided hepatic parenchymal cell growth factor obtained by recombinant DNA technology, a gene coding for the factor, an expression vector capable of expressing the gene, a cell, in particular animal cell, transformed with the expression vector, and a process for producing the hepatic parenchymal cell growth factor.

Hepatic parenchymal cell growth factor gene encoding the same, process

The present invention provides a GTP binding protein containing the following amino acid sequence, with a molecular weight of about 22K dalton and having GTP binding activity which is inhibited by N-ethyl-maleimide and GTP hydrolyzing activity: Thr-Ile-Glu-Asp-Ser-Tyr, and a method for the production of a GTP binding protein, which comprises introducing a DNA fragment containing DNA that encodes the GTP binding protein into a cloning site present at the downstream to a promoter of an expression vector, then introducing the expression vector thus constructed into a host, culturing said host, thereby expressing and accumulating the GTP binding protein and then collecting thereof.

Mutant Smg p21 protein with GTP binding activity

Provided herein are a DNA fragment which contains a base sequence coding for a non-A non-B hepatitis-specific antigenic protein occurring in cells of the liver affected with non-A non-B hepatitis, an expression vector in which said DNA fragment is inserted into a cloning site present downstream from a promoter thereof, a transformant obtained by introducing said expression vector into a host, and a process for producing said antigenic protein which comprises providing said expression vector, transforming a host with said expression vector, culturing the transforming host and collecting the protein produced therein.

DNA fragments coding for antigens specific to non-A non-B hepatitis,

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Machida, Japan

Rie Matsui