Mitsubishi Chemical Corporation

Rie Kawamoto

Kazutoshi Watanabe

Ryoichi Ando

Ken-ichi Saito

Aya Shoda

A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein Rrepresents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; Rrepresents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, Rrepresents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as Alzheimer disease.

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Kanagawa, Japan

Rie Kawamoto