Enzo Biochem, Inc.

Riddhi Bhattacharyya

Dakai Liu

Xiaofeng Li

Richard Jin

Wei Cheng

Elazar S Rabbani

James J Donegan

Yazhou Zhang

Guangrong Zhang

Vincenzo Enea

Yuaxin Liang

Elazar Rabbani

Yuanxing Liang

The present invention relates to the field of therapeutic methods, compositions and uses thereof, that affect, directly or indirectly, the behavior of LRP receptors. These compositions and methods result in the treatment of inflammatory, immunological and metabolic conditions. More particularly, the methods and compositions of the invention are directed to the identification of small molecules, drugs and/or pharmacological agents that affect the Wnt pathway by affecting normal complex formation among various signaling receptors, the LRP5 and LRP6 receptor, and related ligands.

Method for treating crohn'S disease or ulcerative colitis by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain

The present invention relates to the field of therapeutic methods to screen for compounds on the basis of their ability to influence Wnt activity. The screening process is applied to both a physical library of a series of compounds and a virtual library of compounds that affect Wnt activity. In one aspect, the virtual screening process could be carried out where a permutational library of small peptides is substituted for the small organic molecules. The inventive methods may be used to empirically test for effects on Wnt activity and may also be applied to any pair of proteins involved in protein-protein interactions.

Compounds and assays for controlling Wnt activity

Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain

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West Babylon, NY, United States of America

Riddhi Bhattacharyya