Optiscan Biomedical Corporation

Other

Georgia Tech Research Corporation

Sandia Corporation

Yellowstone Diagnostics Corporation

University of California

Sandia National Laboratories

Adeza Biomedical Corporation

Wetland Optics, LLC.

Rick P Trebino

James Roswell Braig

Daniel S Goldberger

Bernhard B Sterling

Arthur Melvin Shulenberger

Charles E Kramer

Richard A King

Peng Zheng

Eric K Gustafson

Casper W Barnes

John Lee

Scott E Bisson

Pablo Gabolde

Pamela Bowlan

Daniel James Kane

Nicholas Michael Sampas

Andreas Sebastian Bommarius

Yuh-Geng Tsay

Emanuel Calenoff

Phillip Ray Gibbs

Bruce A Richman

Erkin Sidick

Marco A Krumbuegel

Arthur Smirl

Mark W Kimmel

Rogelio O Herrera

Kenneth W DeLong

Carl Hayden

Ken DeLong

Alexander Gerson Jacobson

David N Fittinghoff

John N Sweetser

Thomas Tsang

Various methods and systems are provided for generation of a laser pulse with massive pulse-front tilt (PFT) and its use for measurement of laser pulses. In one embodiment, a method includes directing a laser pulse into an etalon and propagating the laser pulse through the etalon to form a tilted pulse. Another embodiment involves directing pulses into an etalon and propagating the pulses through the etalon in opposite directions to form a pair of massively tilted pulses that are tilted in opposite directions. In another embodiment, a system includes a Fresnel biprism configured to produce a pair of pulses from an input pulse and a lens configured to direct each pulse through an opening (or openings) in an input surface of an etalon, where the etalon is configured yield a pair of pulses tilted in opposite directions, each pulse having a massive PFT.

Extreme light pulse-front tilt and its application to single shot measurement of picosecond to nanosecond laser pulses

Various systems and methods for analysis of optical pulses are provided. In one embodiment, an optical system is provided having an optical axis. The optical system includes a two-dimensional diffraction grating positioned along the optical axis, and a spectral filter positioned along the optical axis after the two-dimensional diffraction grating. The spectral filter is angularly offset about a vertical transverse angle associated with the optical system. The diffraction grating is angularly offset about the optical axis relative to the spectral filter, and an optical capture device positioned after the spectral filter.

Determining electric field characteristics of laser pulses

Disclosed are an apparatus and methods for determining electric field characteristics of pulses. In one example, a method is provided in which an unknown pulse is propagated through a first optical fiber. A reference pulse is propagated through a second optical fiber. The unknown pulse and the reference pulse are directed out of the first and second optical fibers into a spectrometer. The unknown pulse and the reference pulse propagate along a pair of crossing trajectories through the spectrometer to form an interferogram. The electric field of the unknown pulse is determined by processing this interferogram.

Use of crossed-beam spectral interferometry to characterize optical pulses

A pulse compressor. In one embodiment, the pulse compressor comprises an optical medium adapted for receiving a beam of light in an incident optical path and dispersing it into its constituent spectral colors to form a dispersed beam of light in an output optical path, where the optical medium is configured such that when an incident beam of light is received by the optical medium, it passes through the optical medium four times, in a back and forth manner, and leaves the optical medium in the form of a corresponding output beam of light.

Ultrashort pulse compressor

A new generation polarimetry apparatus and methodology is disclosed, which involve passing polarized light through a sample including a chiral analyte, where the analyte is under the influence of a periodically varying magnetic field. The apparatus also utilizes optical heterodyne detection and lock-in detection at higher order harmonics of the magnetic field modulation frequency to improve sensitivity and detection limits of optical properties of chiral analytes.

High-throughput chiral detector and methods for using same

A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

Method for determining analyte concentration using periodic temperature modulation and phase detection

An electromagnetic wave analyzer determines intensity and phase characteristics of an electromagnetic wave such as an ultrashort laser pulse. The analyzer passes the electromagnetic wave through a Fresnel biprism that produces a probe pulse and a gated pulse. The probe pulse and the gated pulse intersect and interact in a nonlinear optical medium, such as a second harmonic generating (SHG) crystal. The nonlinear optical medium then time gates and frequency filters the electromagnetic wave producing an input pulse gated signal. A lens maps delay in a horizontal direction and crystal output angle in a vertical direction. A camera detects the output of the lens and creates a spectrogram of the electromagnetic wave.

Electromagnetic wave analyzer

Achromatic phase-matching (APM) is used for efficiently multiplying the frequency of broad bandwidth light by using a nonlinear optical medium comprising a second-harmonic generation (SHG) crystal. Stationary optical elements whose configuration, properties, and arrangement have been optimized to match the dispersion characteristics of the SHG crystal to at least the second order. These elements include a plurality of prismatic elements for directing an input light beam onto the SHG crystal such that each ray wavelength is aligned to match the phase-matching angle for the crystal at each wavelength of light to at least the second order and such that every ray wavelength overlap within the crystal.

Apparatus and methods for using achromatic phase matching at high orders of dispersion

Method for determining analyte concentration using periodic temperature

A spectrometer for the non-invasive generation and capture of thermal gradient spectra from human or animal tissue. The spectrometer includes an infrared transmissive thermal mass for inducing a transient temperature gradient in the tissue by means of conductive heat transfer with the tissue, and cooling means in operative combination with the thermal mass for cooling the thermal mass. Also provided is an infrared sensor means for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the tissue, and for providing output signals proportional to the detected infrared emissions. Data capture means is provided for sampling the output signals received from the infrared sensor means as the transient temperature gradient progresses into the tissue.

Non-invasive infrared absorption spectrometer for the generation and

Spectrometric methodology for non-invasively obtaining optical spectra from heterogeneous material for the identification and quantification of constituent compounds. There is provided a transient or steady state subsurface thermal gradient spectroscopic methodology for obtaining in vivo optical spectra relating to the concentration of n analytes at depths to around 330 microns in human tissue, and for determining that concentration from the spectra. The methodology is employable on a wide variety of spectrometric devices, and enables: a real time determination of both surface and reference intensities; a fast, efficient calibration of the spectrometric device; and results in the provision of an analytical parameter which avoids the measurement of the optical path length to enable the extremely accurate calculation of a ratio of concentrations of n analytes in the system under analysis.

Subsurface thermal gradient spectrometry

A noninvasive infrared spectrometer which includes an infrared detector system for measuring the intensity, wavelength, and time varying nature of infrared energy emanating from deep layers within a body. Before detection, the energy emanating from deep within the body passes through layers of that body in the presence of a natural or induced thermal gradient. The measured infrared energy is processed into an absorption spectra and then into a concentration of at least one constituent of the body which concentration may be strongly dependent on the depth into the body. In one embodiment the temperature gradient is induced by chilling the surface of the body to provide a clearer indication of the infrared absorption levels of the deeper constituents. Other embodiments describe the sequential or simultaneous heating and cooling of the heterogenous body to induce and capture the transient infrared absorption spectral information.

Non-invasive infrared absorption spectrometer for measuring glucose or

Practical third-order frequency-resolved optical grating (FROG) techniques for characterization of ultrashort optical pulses are disclosed. The techniques are particularly suited to the measurement of single and/or weak optical pulses having pulse durations in the picosecond and subpicosecond regime. The relative quantum inefficiency of third-order nonlinear optical effects is compensated for through i) use of phase-matched transient grating beam geometry to maximize interaction length, and ii) use of interface-enhanced third-harmonic generation.

Apparatus and method for optical pulse measurement

Growing community of inventors

Livermore, CA, United States of America

Rick P Trebino