Boehringer Mannheim Gmbh

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Rick L Collins

William J Murphy

George R Lennert

Morris J Young

David E Storvick

Daniel L Kennedy

Charles L Thomeczek, Jr

James R Parker

Gary T Neel

Martin T Gerber

James D Morrow

Stefan Weinert

Blaine Edward Ramey

James L Pauley

Zindel Herbert Heller

Robert David Timmerman

James L Maxwell

Peter L Sebastian

Brett S Lewis

Loy M Vail

Edna C Probst

Edna Probst

Loy Maugh Vail

Systems and methods are disclosed for adjusting the delivery times of an insulin delivery profile of an insulin pump, wherein the insulin pump is operable to automatically deliver insulin to a person having diabetes based on an operating time of the internal clock and a delivery time of an insulin delivery profile. The method may comprise receiving a local time zone time from an external local clock, determining whether the operating time of the internal clock differs from the local time zone time by at least a first predetermined amount of time, requesting the person provide a time adjustment value when the operating time of the internal clock differs from the local time zone time by at least the first predetermined amount of time, receiving the time adjustment value from the person, and adjusting the delivery times of the insulin delivery profile based on the time adjustment value when received.

Methods and systems for adjusting an insulin delivery profile of an insulin pump

In combination, an instrument for determining a characteristic of a biological fluid or a control, and a cuvette for holding a sample of the biological fluid or control, the characteristic of which is to be determined. The instrument comprises a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls. The radiation reflective surface is disposed adjacent a second of the two opposed walls. A second source is provided for irradiating the surface. The first detector detects radiation from the second source reflected from the surface. The second source is positioned to transmit radiation through the two opposed walls for reflection by the surface and transmission back through the two opposed walls to the first detector to indicate whether a sample has reached a first point in the cuvette.

Fluid dose, flow and coagulation sensor for medical instrument

An instrument for determining a characteristic of a biological fluid or a control includes a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. A cuvette for use with the instrument holds a sample of the biological fluid or control the characteristic of which is to be determined. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of said two opposed walls and the radiation reflective surface is disposed adjacent a second of said two opposed walls.

An instrument for determining a characteristic of a biological fluid or a control comprises a radiation-reflective surface, a first source for irradiating the surface, a first detector for detecting radiation reflected from the surface, and a mechanism for determining the characteristic based on the detected radiation. A slide holds a sample of the biological fluid or control the characteristic of which is to be determined. The slide has two opposed walls transparent to the radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls. A system is provided for supplying power and regulating supplied power from one of multiple power sources to the instrument. The system comprises first and second power sources, first coupling circuitry for selectively coupling the system to the first power source, second coupling circuitry for selectively coupling the system to the second power source, and circuitry for comparing a voltage supplied by the first power source to a voltage supplied by the second power source and for controlling the first coupling circuitry to decouple the system from the first power source when the voltage supplied by the second power source exceeds the voltage supplied by the first power source.

Power supply monitor and control for medical instrument

An instrument and a method for determining a characteristic of a biological fluid or control comprise providing a radiation-reflective surface, a source for irradiating the surface, a detector for detecting radiation reflected from the surface, and a cuvette for holding a sample of the biological fluid or control. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The source and detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent the other wall. The method comprises detecting radiation from the source reflected from the surface using the radiation detector to determine a characteristic of the biological fluid or control.

A method of immunizing the operation of an instrument which determines a characteristic of a biological fluid or a control against noise. The instrument includes a surface upon which a user deposits a sample of biological fluid or control the characteristic of which is to be determined. The instrument irradiates the sample and detects radiation from the sample to determine the characteristic. The method comprises monitoring the detected radiation a first time to determine if the detected radiation is increasing or decreasing, forming a first change in detected radiation from said first monitoring, subsequently monitoring the detected radiation a second time to determine if the detected radiation is increasing or decreasing, forming a second change in detected radiation from said second monitoring, forming an overall change in detected radiation from the first and second monitorings, establishing a first threshold, establishing a second threshold, comparing the first change to the first threshold, comparing the second change to the first threshold, if the magnitudes of both the first and second changes are greater than the first threshold, comparing the overall change in radiation to the second threshold, and determining the characteristic if the magnitudes of the first and second changes are greater than the first threshold and the overall change is greater than the second threshold.

A method of determining whether a sample or a control has been applied to an instrument for measuring coagulation of a fluid by optically detecting when the fluid that has been applied to the instrument has passed a first and a second points, determining the flow time for the fluid between the two points, establishing a time threshold, and the flow time to the threshold to determining if the fluid is a sample or a control.

Fluid dose flow and coagulation sensor for medical instrument

A method for calculating a coagulation characteristic of a sample of blood, a blood fraction, or a control comprises generating an output signal indicative of coagulation of the sample, sampling the output signal at a sampling rate for a predetermined time to provide a plurality of sampled signal values, storing the sampled signal values, rectifying the stored sampled signal values to provide a plurality of envelope values, and storing the envelope values. The stored envelope values are examined in reverse time order to determine a slope of the envelope at each of the stored envelope values. All relative maxima in the stored envelope values are identified. A range of stored envelope values corresponding to each relative maximum is determined. The identified relative maxima are compared to locate an absolute maximum in the stored envelope values. The coagulation characteristic is then calculated from the stored envelope values within the predetermined range of envelope values corresponding to the absolute maximum.

Method and apparatus for calculating a coagulation characteristic of a

An instrument and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface, a first source for irradiating the surface, and a first detector for detecting radiation reflected from the surface. A cuvette holds a sample of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette has two opposed walls substantially transparent to the source radiation and reflected radiation. The first source and first detector are disposed adjacent a first one of the two opposed walls and the radiation reflective surface is disposed adjacent a second of the two opposed walls.

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Cicero, IN, United States of America

Rick L Collins