Bristol-myers Squibb Compnay

Richard Yu-Cheng Huang

Guodong Chen

Aaron Paul Yamniuk

Achal Mukundrao Pashine

Stephen Michael Carl

Michael L Gosselin

Ekaterina G Deyanova

Priyanka Apurva Madia

Derek A Holmes

Scott Ronald Brodeur

Lin Hui Su

Yun Wang

Alfred Robert Langish

Hong Shen

Paul O Sheppard

Alan J Korman

Mark J Selby

Brigitte Devaux

Michelle Minhua Han

Huiming Li

Michelle Renee Kuhne

Xiao Min Schebye

Christine Bee

Daniel F Ardourel

Andy X Deng

Hong-An Truong

Anan Chuntharapai

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Antibodies against TIM3 and uses thereof

Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Nucleic acids encoding anti-TREM-1 antibodies

Anti-TREM-1 antibodies and uses thereof

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Antibodies against IL-7R alpha subunit and uses thereof

Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more Fc&#x3b3;Rs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R&#x3b1;). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Growing community of inventors

Bridgewater, NJ, United States of America

Richard Yu-Cheng Huang