Pavmed Inc.

Cornell University

Lumendi Ltd.

Case Western Reserve University

Richard Yazbeck

Lishan Aklog

Stephen C Evans

Timothy Robinson

Michael P Boutillette

Jeffrey Milsom

Tuan Anh Nguyen

Sameer Sharma

Jeremy A Van Hill

Ashley Lauren Whitney

Matthew DeNardo

Gabriel Greeley

John Frederick Cornhill

Anthony Z Assal

Rahul Sathe

Christopher Dillon

Dennis Siedlak

Audrey R Bell

Alan Fortunate

William Rebh

Shaun O'Neil

Peter Aliski

Brian David Chouinard

Phal Kun Chan

Sanford D Markowitz

Brian Justo deGuzman

Amitabh Chak

Joseph Willis

Samuel V Verplanck

Jonathan O'Keefe

Amos Cruz

Taylor Bensel

Julian Fricks

Jessie Gifford

Brian Deguzman

Gregory Eberl

Matthew Denardo

Phala Chan

The present invention relates to a catheter construction and method of use suitable for use in navigating within a body lumen or vessel, such as a vein, artery, nasal cavity, esophagus, etc. to assist in the performance of various procedures. The device can include a flexible tubular member having a proximal end, a distal end, and channel extending substantially between the proximal end and the distal end, a stiffening sleeve positioned at the distal end of the tubular member to provide stiffness thereto so that a removable procedural tool can be attached to the tubular member, and an elongated non-elastic tether situated within the channel of the tubular member and secured at one end to the distal end of the member, such that when the tether is held in tension, the tether acts to minimize the tubular member from deviating from a neutral state.

Catheter device system and method of use

A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

Device for biological cell collection and method of use

Systems and methods for exhausting air from a flow pathway are provided. The systems can include a flow resistor having an input coupled to a fluid source and an outlet to output a fluid at an output flow rate, the flow resistor including an adjustable flow channel for modifying the output flow rate of the fluid flowing through the flow resistor; and a priming device having an elongated portion, the elongated portion being substantially rigid axially and configured for insertion through the outlet of the flow resistor to engage the flow resistor and adjust the output flow rate to allow air to be exhausted from the flow pathway through the flow resistor.

Systems and methods for priming a fluid line

A device for dividing a fibrous structure comprising an expandable member positioned near the distal end of a catheter and in fluid communication with the lumen of the catheter so that the expandable member can be biased between an inflated state and a deflated state to tension the fibrous structure, and electrosurgical elements situated on or proximate to an outer surface of the expandable member and configured to deliver electrical and thermal energy to the tensioned fibrous structure in a manner that results in division of the tensioned fibrous structure. A method for dividing a fibrous structure comprising positioning proximate the fibrous structure an expandable member having electrosurgical elements, expanding the expandable member outwards to tension the fibrous structure across the electrosurgical elements, and activating the electrosurgical elements to deliver energy to the tensioned fibrous structure to divide the tensioned fibrous structure.

Systems and methods for minimally-invasive division of fibrous structures

The systems and methods of the present disclosure provides an independent passive variable resistor that can be interposed between a fluid reservoir at an inlet pressure and receptacle at an outlet pressure. The resistor can adjust resistance to the pressure difference from the input to the output so that the flow rate through it is a constant rate. The resistor can include a moveable element and a biasing mechanism located in a chamber to create a flow channel. Each side of the moveable element is exposed to the inlet and outlet pressures and moves within the flow channel to modify the resistance of the flow through the chamber in response to the pressures. The balance of these forces determines the position moveable element, which interacts with the fluid channel to determine the flow resistance through variable resistor. The biasing mechanism can provide the necessary pressure to establish equilibrium flow rate.

Systems and methods for a variable flow resistor

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the axial opening is closed down.

Method and apparatus for manipulating the side wall of a body lumen or body cavity so as to provide increased visualization of the same and/or increased access to the same, and/or for stabilizing instruments relative to the same

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Norwell, MA, United States of America

Richard Yazbeck