King's College London

Gammadelta Therapeutics Ltd

Cancer Research Technology Limited

The Francis Crick Institute Limited

Richard Woolf

Adrian Hayday

Oliver Nussbaumer

Natalie Mount

Maria Luisa Iannitto

Richard Esmond Beatson

Richard Beatson

The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., a part of an adoptive T cell therapy).

Expansion of γδ T cells, compositions, and methods of use thereof

The present invention provides methods of expanding &#x3b3;&#x3b4; T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded &#x3b3;&#x3b4; T cells and methods of using the expanded &#x3b3;&#x3b4; T cells (e.g., apart of an adoptive T cell therapy).

Expansion of &#x3b3;&#x3b4; T cells, compositions, and methods of use thereof

This invention relates to the expansion of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cells and uses thereof.

Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells

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Richard Woolf