Euticals Gmbh

Archimica Gmbh

Richard Wisdom

Andreas Meudt

Joerg Jung

Bernd Wilhelm Lehnemann

Jason Helmke

Quofang Qiu

Paul Meek

Jörg Jung

The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.

Process for the asymmetric transfer hydrogenation of ketones

The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20&#xb0; C. 

Process for producing lacosamide

The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.

Process for the synthesis of amphetamine derivatives

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Eppstein, Germany

Richard Wisdom