Wyeth

Therapeuticsmd, Inc.

Richard Winneker

Andrew Fensome

Diane Deborah Harrison

Gary Sondermann Grubb

Puwen Zhang

Eugene Anthony Terefenko

Jeffrey Curtis Kern

Julia M Amadio

Peter H R Persicaner

Thorsteinn Thorsteinsson

Annette M Shadiack

Jason D Legassie

Ajay Ghanta

This disclosure relates to transdermal pharmaceutical compositions containing progesterone in combination with one or more solubilizing agents and penetration enhancers, wherein the pharmaceutical compositions are formulated as creams for topical administration. In some embodiments, the transdermal pharmaceutical compositions contain progesterone, a medium-chain oil, and d-limonene. In some embodiments, the transdermal pharmaceutical compositions contain progesterone, a medium-chain oil, a penetration enhancer (e.g., propylene glycol, a fatty acid ester of propylene glycol, a glycol ether), and optionally d-limonene. In certain embodiments, the pharmaceutical compositions further include estradiol. Methods for treating conditions associated with hormone deficiency in a subject are also described.

Transdermal cream

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R-Rand Qare defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Methods of treating hormone-related conditions using thio-oxindole derivatives

The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R-Rand Qare defined as described herein. Specifically, methods for treating acne, hirsutism, and conditioning the skin are described. Also provided are novel PR modulators of formula II.

Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders

The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R&#x2013;Rand Qare defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Methods of treating hormone-related conditions using cyclothiocarbamate derivatives

The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R&#x2013;Rand Qare defined as described herein. Specifically, methods for treating acne, hirsutism, and a composition for conditioning the skin are described.

Methods of treating skin disorders using thio-oxindole derivatives

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Penllyn, PA, United States of America

Richard Winneker