Euro-celtique S.a.

Richard William Frith

Mark Chasin

David J Cavalla

Lloyd Jay Dolby

Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of:

Phenyl-triazole compounds for PDE-IV inhibition

Novel compounds which are effective PDE IV inhibitors are disclosed. These compounds have the general structure of: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, X.sub.1, X.sub.2 and Z are described herein. The compounds possess improved PDE IV inhibition as compared to rolipram as well as with improved selectivity with regard to PDE III inhibition. Pharmaceutical compositions containing the same and methods of treatment are also disclosed.

Aryl imidazole compounds having phosphodiesterase IV inhibitory activity

Novel compounds which are effective PDE IV inhibitors are disclosed The compounds possess similar or improved PDE IV inhibition as compared to rolipram, with improved selectivity with regard to, e.g., PDE III inhibition. Preferred compounds are 3-(3-cyclopentyloxy-4-methoxy-benzylamino)-4-hydroxymethyl pyrazole and 3-(3-cyclopentyloxy-4-methoxybenzylamino)-4-methoxymethylpyrazole.

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Cambridge, United Kingdom

Richard William Frith