Ferring B.v.

Ferring International Center Sa.

Richard White

Daniel Plaksin

Ian Cottingham

Jonathan Daugherty

Deborah Ashworth

Alvin Kaplan

Joel Kaplan

Described are pharmaceutical compositions comprising recombinant human chorionic gonadotropin (hCG) and optionally follicle stimulating hormone (FSH), wherein the recombinant hCG in the composition comprises α2,3- and α2,6-sialylation and comprises mono-(1S), di-(2S), tri-(3S) and tetra-(4S) sialylated glycan structures. The recombinant hCG may be obtained by expression in a human cell line, such as the PER.C6 cell line, optionally wherein the cell line is modified using α2,3-sialyltransferase.

Pharmaceutical preparation comprising recombinant HCG

Preparations including recombinant FSH (rFSH).

Pharmaceutical preparation

Described are pharmaceutical compositions comprising recombinant human chorionic gonadotropin (hCG) and follicle stimulating hormone (FSH), wherein the recombinant hCG in the composition comprises &#x3b1;2,3- and &#x3b1;2,6-sialylation and comprises mono-(1S), di-(2S), tri-(3S) and tetra-(4S) sialylated glycan structures. The recombinant hCG may be obtained by expression in a human cell line, such as the PER.C6 cell line, optionally wherein the cell line is modified using &#x3b1;2,3-sialyltransferase.

Pharmaceutical preparation comprising recombinant hCG

The present disclosure describes recombinant human chorionic gonadotropin (hCG) and methods for the production thereof. The recombinant hCG can include &#x3b1;2,3, &#x3b1;2,6, and, optionally, &#x3b1;2,8 sialylation. The recombinant hCG can be produced in a human cell line such as a PER.C6&#xae; cell line.

Pharmaceutical preparation comprising recombinant HcG

Recombinant FSH including alpha 2,3- and alpha 2,6-sialylation

The present disclosure describes recombinant follicle stimulating hormone (FSH) and methods for the production thereof. The recombinant FSH can include &#x3b1;2,3, &#x3b1;2,6, and, optionally, &#x3b1;2,8 sialylation. The recombinant FSH can be produced in a human cell line such as a PER.C6&#xae; cell line.

Growing community of inventors

San Diego, CA, United States of America

Richard White