Chdi Foundation, Inc.

Richard Waldron Marston

Celia Dominguez

John Wityak

Michael Edward Prime

Peter David Johnson

Christopher John Brown

Jonathan Bard

Daniel Clark-Frew

Sarah Hayes

Samuel Coe

Thomas Martin Krulle

Matthew Robert Mills

Duane Higgins

Samantha Brown

Stephen Martin Courtney

Douglas Macdonald

Frederick Arthur Brookfield

Christopher John Yarnold

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use. 

Probes for imaging huntingtin protein

Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use 

Probes for imaging Huntingtin protein

Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.

Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof

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Wantage, United Kingdom

Richard Waldron Marston