The General Hospital Corporation

University of Southern California

Massachusetts General Hospital Corporation

Richard W Roberts

Jack W Szostak

Rihe Liu

Stephen V Fiacco

Terry T Takahashi

Jason Junge

Don B Arnold

Garrett G Gross

Rudy Mora

Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability. The methods can be applied to similar peptides for the making of therapeutic compositions.

Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same

Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein.

Antibody and antibody mimetic for visualization and ablation of endogenous proteins

Described herein are RNA-protein fusion production methods which involve a high salt post-translational incubation step.

Selection of proteins using RNA-protein fusions

Nucleic acid-protein fusions and methods of making and selecting fusions

Described herein are methods and reagents for the selection of protein molecules that make use of RNA-protein fusions.

RNA-antibody fusions and their selection

Nucleic acid-protein fusion molecules and libraries

Method for selection of proteins using RNA-protein fusions

Libraries of protein encoding RNA-protein fusions

Growing community of inventors

South Pasadena, CA, United States of America

Richard W Roberts