City University of New York

New York University

Aaron Diamond Aids Research Center

Richard W Franck

Moriya Tsuji

Guangwu Chen

Guangli Yang

Yaoxing Huang

John Schmieg

The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.

C&#x2014;glycolipids with enhanced Th-1 profile

The invention is directed to compounds of formula (I) wherein X is O or NH; R' is a hydrocarbon chain; Rand Rare hydrogen, OH or a monosaccharide; Ris hydrogen or a monosaccharide; Q&#x2032; is optionally present and may be a Chydrocarbon; X&#x2032; is optionally present and may be O, S or NR; and Qmay be a hydrocarbon or hydrogen. The invention is also directed to the use of the compounds for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the compounds of formula (I).

Synthetic C-glycolipid and its use for treating cancer, infectious diseases, and autoimmune diseases

The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes a synthetic glycolipid compound of Formula I, as described herein. According to the present invention, the use of a compound of Formula I as an adjuvant is attributed at least in part to the enhancement and/or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.

Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases

Synthetic C-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases

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Riverside, CT, United States of America

Richard W Franck