Nps Pharmaceuticals, Inc.

Myrexis, Inc.

Myriad Pharmaceuticals, Inc.

Richard Trovato

Bradford C Van Wagenen

Scott T Moe

Manuel F Balandrin

Eric G DelMar

Ashok Bajji

Mark B Anderson

Daniel Wettstein

Rajendra Tangallapally

Mark Shenderovich

Se-Ho Kim

Benjamin Markovitz

John A Vanecko

Thomas M Stormann

Daryl Lynn Smith

Robert M Barmore

Ruth J Walton

Susan M Sheehan

Eric Delmar

Irina V Shcherbakova

The invention relates to compounds of Formulae I-III: and therapeutic uses thereof, wherein A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carbocyclic group; B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group; R1 is chosen from hydro, alkyl, aryl, heteroaryl, amino, or halo; and L, L, are as defined herein.

Purine-core inhibitors of HSP90 and their use in treating cancer

The invention relates to compounds of Formula I and their therapeutic uses, wherein substituent A is chosen from a substituted or unsubstituted aryl, heteroaryl, heterocyclic, or carboxylic group, B is chosen from a substituted or unsubstituted piperidine, homopiperidine, piperazine, pyrrolidine or azetidine group, R1 is chosen from hydro, alkyl, aryl, heteroaryl amino and halo, and L1 and L2 are as defined in the specification.

Therapeutic compounds and their use in cancer

The present invention provides compounds, and pharmaceutical compositions containing those compounds, that are active at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases

The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.

Inorganic ion receptor-active compounds

Inorganic ion receptor active compounds

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Salt Lake City, UT, United States of America

Richard Trovato