Immusol, Incorporated

Promising Future, LLC

Richard Tritz

Jack R Barber

Mang Yu

Peter J Welch

Soonpin Yei

Markley C Leavitt

Yu Feng

Joan M Robbins

Carol A Kruse

Tsvi Goldenberg

Elizabeth Duarte

Provided herein are methods and compositions for killing tumor cells. In certain embodiments, compositions can promote apoptosis by down-regulating FAPP2 and PATZ1 products.

Fas/FasL or other death receptor targeted methods and compositions for killing tumor cells

As an effective therapy for proliferative skin and eye diseases such as psoriasis and proliferative diabetic retinopathy, this invention provides ribozymes and ribozyme delivery systems which cleave RNA encoding cytokines involved in inflammation, matrix metalloproteinases, a cyclin, a cell-cycle dependent kinase, a growth factor, or a reductase.

Ribozyme therapy for the treatment of proliferative skin and eye diseases

The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.

Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries

This invention provides ribozymes useful to treat or prevent Hepatitis C Virus (&ldquo;HCV&rdquo;) infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes usefull in methods of treatment and prevention of HCV infection or disease are also provided.

Hepatitis C Virus ribozymes

This invention provides ribozymes useful to treat or prevent Hepatitis C Virus ('HCV') infection or disease in an organism or subject, as well as methods of treating an HCV infection or disease. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes useful in methods of treatment and prevention of HCV infection or disease are also provided.

Hepatitis C virus ribozymes

Methods of inhibiting HIV infection by blocking HIV co-receptor RNA expression are provided. Ribozymes which cleave HIV co-receptor RNA and inhibit HIV infection of cells are also provided. Co-receptor targets include fusin and CKR5.

Methods and compositions for inhibiting HIV infection of cells by

As an effective therapy for restenosis, this invention provides ribozymes and ribozyme delivery systems useful to inhibit abnormal smooth muscle cell proliferation in vascular tissue. Methods of producing ribozymes and gene therapy utilizing these ribozymes also are provided.

Ribozyme therapy for the inhibition of restenosis

GUC and GUA ribozymes which cleave HIV RNA are provided. The ribozymes cleave HIV RNA in vitro and in vivo. When the ribozymes are expressed in cells, they inhibit HIV replication in the cells.

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San Diego, CA, United States of America

Richard Tritz