Hollis-eden Pharmaceuticals, Inc.

Cytodyn Inc.

Richard Trauger

James M Frincke

Steven K White

Clarence Nathaniel Ahlem

Christopher Reading

Dwight Stickney

Theodore M Page

Dominick L Auci

Charles Dowding

Mei Li

Provided are felinized antibodies and methods for treating or reducing the likelihood of developing a retroviral infection in a feline, decreasing retroviral virion entry into a feline cell, decreasing retroviral virion budding from a feline cell, or decreasing syncytium transmission in a feline. These methods require the administration of at least one felinized antibody or fragment thereof that specifically binds to CD11a and/or CD18, or ICAM-1, and/or decreases or prevents the binding of LFA-1 (CD11a/CD18 heterodimer) to ICAM-1. Also provided are veterinary compositions and methods of identifying candidate agents useful for treating or reducing retroviral infection in a feline, decreasing retroviral virion entry into a feline cell, decreasing retroviral virion budding from a feline cell, or decreasing syncytium transmission in a feline.

Felinized antibodies and methods of treating retroviral infections in felines

The invention relates to the use of compounds to ameliorate or treat a condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3&#x3b2;-hydroxy-17&#x3b2;-aminoandrost-5-ene, 3&#x3b2;-hydroxy-16&#x3b1;-fluoro-17&#x3b2;-aminoandrost-5-ene, 3&#x3b1;-hydroxy-16&#x3b1;-fluoro-17&#x3b2;-aminoandrost-5-ene, 3&#x3b2;-hydroxy-16&#x3b2;-fluoro-17&#x3b2;-aminoandrost-5-ene, 1&#x3b1;,3&#x3b2;-dihydroxy-4&#x3b1;-fluoroandrost-5-ene-17-one, 1&#x3b1;,3&#x3b2;,17&#x3b2;-trihydroxy-4&#x3b1;-fluoroandrost-5-ene, 1&#x3b2;,3&#x3b2;-dihydroxy-6&#x3b1;-bromoandrost-5-ene, 1&#x3b1;-fluoro-3&#x3b2;,12&#x3b1;-dihydroxyandrost-5-ene-17-one, 1&#x3b1;-fluoro-3&#x3b2;,4&#x3b1;-dihydroxyandrost-5-ene and 4&#x3b1;-fluoro-3&#x3b2;,6&#x3b1;,17&#x3b2;-trihydroxyandrostane.

Therapeutic treatment methods

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Leucadia, CA, United States of America

Richard Trauger