Regeneron Pharmaceuticals, Inc.

Applikate Technologies LLC

Levene, Michael

Torres, Richard

Richard Torres

Lynn Macdonald

Joel H Martin

Marc R Morra

Joel C Reinhardt

Michael Levene

Paul Tiseo

Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved.

Method of treating osteoarthritis with an antibody to NGF

A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with Kof 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

High affinity human antibodies to human nerve growth factor

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New York, NY, United States of America

Richard Torres