University of California

Cornell University

Memorial Sloan Kettering Cancer Center

Richard Ting

Roger Y Tsien

Omer Aras

Erik Rodriguez

John Lin

Geraldine Tran

Feifei An

Nandi Chen

A compound according to Formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein Xand Xare each independentlyF orF; Rand Rare each independently alkyl, amine, perfluoroalkyl, alkenyl, alkynyl, aryl, or aralkenyl; and Ris H, halo, alkyl, alkyl ester, alkenyl, alkynyl, aryl, or aralkenyl; or wherein: Rand Ror Rand Rjoin to form a 6-membered cycloalkyl or heterocyclyl; or Rand R, Rand R, or R, R, and Rjoin to form a substituted or unsubstituted polycyclic ring, wherein the polycyclic ring comprises fused cycloalkyl, heterocycloalkyl, aryl, or heteroaryl rings.

One-step, fast, 18F-19F isotopic exchange radiolabeling of difluoro-dioxaborinins and use of such compounds in treatment

The invention provides evolved red-shifted smURFPs. In some embodiments, the smURFPs are characterized by a) increased Fluorescence of smURFP as compared to infrared FPs IFP1.4 and iRFP713; b) expressing efficiently with minimal toxicity; c) does not require a lyase to covalently attach its chromophore, wherein the chromophore is biliverdin; d) exhibit a wavelengths longer than attainable with jellyfish- or coral-derived FPs using smURFP and IFP2.0; e) allows for functional fusion to hCdt1(30/120) as compared to jellyfish- or coral-derived FPs mAG, eGFP, and mRFP1 which are nonfunctional; and f) allows for deep tissue imaging.

Allophycocyanin alpha-subunit evolved labeling proteins (smURFPs)

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New York, NY, United States of America

Richard Ting