Fresenius Medical Care Deutschland Gmbh

Mdc Max-delbruck-centrum Fur Molekulare Medizin Berlin-buch

Richard Straube

Gerd Wallukat

Rudolf Kunze

Peter Rosenthal

A peptide having an EDof less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular &#x3b1;1 loop 2 or &#x3b2;2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of &#x3b3;-secretase activity, an increased release of &#x3b2;-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the EDvalue is measured by bioassay.

Peptides having binding affinity to an antibody which recognizes an epitope on an &#x3b1;1 loop 2 or &#x3b2;2 loop 1 of an adrenoreceptor

A peptide having an EDof less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular &#x3b1;1 loop 2 or &#x3b2;2 loop 1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of &#x3b3;-secretase activity, an increased release of &#x3b2;-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the EDvalue is measured by bioassay.

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Ludenscheid, Germany

Richard Straube