Synecor LLC

Boston Scientific Scimed, Inc.

Advanced Cardiovascular Systems, Inc.

Duke University

Other

Barosense, Inc.

Interventional Autonomics Corporation

Transenterix, Inc.

Nuxcel, Inc.

Nuxcel2 LLC

Transenterix Surgical, Inc.

Corvascular Surgical Systems, Inc.

Minimally Invasive Surgical Access Limited

Richard S Stack

Richard Glenn

William L Athas

Michael Scott Williams

John P Lunsford

Fred E Silverstein

Nathan Every

Trevor Moody

William Joseph Boyle

William S Eubanks

Daniel J Balbierz

Daniel Wayne Fifer

Kevin Johnson

Geoffrey Orth

Dan Balbierz

Jonathan S Stamler

Eric John Toone

Kevin H Van Bladel

Terrance J Ransbury

William E Sanders

Lynn H Elliott

Jeffrey A Smith

Stephen C Masson

Paul F Muller

Udayan G Patel

Kent C B Stalker

Benjamin C Huter

Scott Jason Huter

Emer M Feerick

Richard Kouri

Colleen Stack N'diaye

Matthew Moran

Andy Edward Denison

Samuel T Crews

Shuji Uemura

Christopher J Tarapata

Ashik A Mohan

Damian Muldoon

Denise Ching

Colleen Stack

Liam Ruddy

John D Whitfield

Myron L Wolbarsht

James H McElhaney

William Cannon

William Eubanks, Jr

William S Eubanks, Jr

Aurora Pryor

Michael S William

Rory O'Brien

Robert H Hawes

Paul V Neale

Matthew J Fitz

Michael Hogendijk

William F Walker

Christopher C Andrews

Hugh L Narciso, Jr

Charles R Peterson

Salvatore Castro

Samir R Patel

Francis G Duhaylongsod

Christopher M O'Connor

Troy Chapman

Kenneth J Weeks

Kenneth W Lyles

Cathleen S Colon-Emeric

Donald Schwarten

Harry R Phillips, Iii

Zemaida P Klopovic

Zenaida P Klopovic

Howard G Clark

Richard Phelan

Sergio Correa

Brad Jordan

Robert T Hawes

Richard A Glenn

Geoffrey A Orth

Trevor J Moody

Michael S Williams

Jeff Smith

Colleen Stack N'DIAYE

Colleen Stack-D'NIAYE

Shuji Vemura

Sam Crews

Ashik Mohan

Rob Hawes

To percutaneously deliver a replacement tricuspid valve, a cable is percutaneously positioned with a first end extending out of the venous vasculature at the neck, and a second end extending out of a femoral access point. An eyehook device is positioned over the first end. A tricuspid valve delivery device (TVDD) is advanced over the second end, and then advanced through an IVC into a right atrium. The eyehook device is advanced into the right ventricle, drawing an intermediate portion of the cable into the right ventricle. Contact between the distal end of the eyehook device and the right ventricle is maintained while the TVDD is pushed from the femoral vein. The intermediate portion of cable applies a force to a distal nose of the TVDD that causes the distal nose to be steered into a tricuspid valve annulus as the TVDD is advanced.

Device and method for percutaneously delivering a tricuspid valve

A system and method used to deliver a valve delivery system carrying a valve to a target valve annulus in the heart includes a cable percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, transseptally through the heart, to a femoral artery. The valve delivery system device is passed over an end of the cable at the arterial side and is secured to the cable. The valve delivery system device is pushed in a distal direction while the venous end of the cable is pulled in the proximal direction, to advance the valve delivery system to the target valve annulus. A left ventricle redirector positionable on the cable from the venous end has a distal end actively steered during advancement and positioning of the valve delivery device, exerting forces that steer the distal nose of the valve delivery device as it moves towards the valve annulus.

Guidewireless transseptal delivery system and method

A system and method used to deliver a percutaneous ventricular assist device (pVAD) or other cardiac therapeutic device to a site within the heart, such as a site at the aortic valve. A flexible device is percutaneously introduced into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The venous-side end of the flexible device is withdrawn out the venous vasculature superior to the heart, and a pVAD is secured to the flexible device. The pVAD is pushed in a distal direction while the arterial-side end of the flexible device is pulled in the proximal direction to advance the pVAD to the target site. A left ventricle redirector aids in orienting the pVAD and preventing migration of the flexible member towards delicate structures of the heart during advancement of the pVAD.

Systems and methods for transseptal delivery of therapeutic devices

A method of treating a patient having a blood pressure comprises delivering neuromodulation therapy to sustain or increase the blood pressure. The neuromodulation therapy includes placing a sympathetic therapy electrode in a posterior portion of a blood vessel and stimulating at least one extravascular cardiac sympathetic nerve fiber using said electrode.

System and method for neuromodulation

An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

Instrument for facilitating transseptal delivery of cardiac therapeutic devices

A conduit for creating a passage from a right atrium to a left atrium, through a mitral valve into the left ventricle, and to provide a passage from the left ventricle into the aortic valve. The conduit includes an elongate tubular member having a shaft with a proximal section and a distal loop section at a distal end of the proximal section. The distal loop section includes a proximal curve, a distal curve, a generally straight segment extending between the curves, and a distal tip. The shaft in the distal loop section curves back on itself so that proximal curve is formed by a part of the shaft that is closer along the length of the shaft to the distal tip. The shapes of the proximal and distal curves are selected to direct the distal tip into the mitral valve after it has crossed the inter-atrial septum from the right atrium to the left atrium of the heart, and to orient the distal opening of the distal tip towards the aortic valve when the proximal curve is in the mitral valve and the distal tip is in the left ventricle.

Conduit for transseptal passage of devices to the aorta

A system and method used to deliver an aortic valve therapeutic device to an aortic valve site includes a cable percutaneously introduced a cable into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transeptal puncture, and to a femoral artery. The therapeutic device is passed over an end of the cable at the venous side and is secured to the cable. The therapeutic device is pushed in a distal direction while the second end of the cable is pulled in the proximal direction to advance the therapeutic device to the mitral valve site. A left ventricle redirector aids in orienting the therapeutic device and preventing migration of the cable towards delicate mitral valve structures and chordae tendoneae during advancement of the therapeutic device.

Guidewireless transseptal delivery system for therapeutic devices of the aortic valve

Percutaneous access sheaths used to provide access to the vasculature and heart for the introduction of percutaneous ventricular assist devices (pVADs), and to remain in place for the duration of pVAD use. The sheaths include actively closeable seals engageable to seal against the drive lines of the pVADs to minimize blood loss during pVAD use.

Percutaneous sheaths for use with percutaneous ventricular assist devices

Systems and methods for transseptal delivery of percutaneous ventricular assist devices and other non-guidewire based transvascular therapeutic devices

A system and method for extracting a pVAD device that is implanted with a distal portion in an aorta of the heart and a drive line extending across an inter-atrial septum and out of the body via a superior vessel of the venous vasculature, include a first device that is introduced into a femoral artery and through the descending aorta used to engage a distal part of the pVAD device in the aorta of a patient using an instrument. A second, cutter, device is introduced into the venous vasculature superior to heart, advanced to a position adjacent the inter-atrial septum, and used to cut the pVAD drive line adjacent to the inter-atrial septum. After cutting, a first portion of the pVAD is withdrawn from the body via the venous vasculature, and a second portion is withdrawn from the body via the femoral artery.

Devices for use in extracting percutaneous ventricular assist devices

A system and method used to deliver a therapeutic device to a target treatment site in the heart includes a cable percutaneously introduced a cable into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The therapeutic device is passed over an end of the cable at the venous side and is secured to the cable. The therapeutic device is pushed in a distal direction while the second end of the cable is pulled in the proximal direction to advance the therapeutic device to the target treatment site. A left ventricle redirector aids in orienting the therapeutic device and preventing migration of the cable towards delicate mitral valve structures and chordae tendoneae during advancement of the therapeutic device.

A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts&#x2014;so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.

Catheter system for acute neuromodulation

The present invention includes a system for quickly and simply manufacturing semi-custom cabinetry utilizing a hidden pin joining system. The hidden pin joining system allows panels of the cabinet to quickly and securely join together, with significant load bearing ability. The different joining pin designs allow for different ways of discretely joining pieces together to create custom cabinetry during installation. The specially designed drill bits allow the system to work seamlessly. Using CAD/CAM machinery, the drill bits can cut stock pieces that can be taken to installation sites, and formed into custom cabinetry for kitchen, closets, or any other desired shelving units.

Modular cabinet with hidden clamping system

The present invention includes a system for quickly and simply manufacturing semi-custom cabinetry utilizing a hidden pin joining system. The hidden pin joining system allows panels of a cabinet, or other items, to quickly and securely join together, with significant load bearing ability. The joining pin designs allow for discretely joining pieces together to create custom cabinetry during installation. The specially designed drill bits allow the system to work seamlessly. Using CAD/CAM machinery, the drill bits can cut stock pieces that can be taken to installation sites, and formed into custom cabinetry for kitchen, closets, or any other desired shelving units.

Growing community of inventors

Chapel Hill, NC, United States of America

Richard S Stack