Syva Company

Richard S Schneider

Michael J Soffer

Steven J Gould

Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine, which in turn are conjugated to antigenic polypeptides for formation of antibodies for use in immunoassays. The antibodies produced, when employed in immunoassays, are found to be able to detect the ingestion of a wide variety of benzdiazepine drugs as determined by positive results with the urine of the patient.

Oxazepam derivatives for immunoassay reagents

Non-oxo-carbonyl substituted derivatives of cocaine are provided for conjugation with other compounds to provide reagents for use in a diversity of immunoassay techniques. Specifically, carboxy or imidoyl derivatives are provided which may be conjugated with antigens for use in the preparation of antibodies to cocaine or conjugated with detector molecules for use in the qualitative or quantitative determination of the presence of cocaine.

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Saratoga, CA, United States of America

Richard S Schneider