Integrated Vascular Systems, Inc.

Cardiothoracic Systems, Inc.

Ensure Medical, Inc.

Core Medical, Inc.

Cardiovascular Imaging Systems, Inc.

Gateway Medical, Inc.

Cardinal Health Switzerland 515 Gmbh

Cardiacmd, Inc.

Ovalis, Inc.

Cordis Corporation

Maquet Cardiovascular LLC

Enable Medical Corporation

Aortx, Inc.

Medical Technology Group

Reduction Technologies, Inc.

Richard S Ginn

William N Aldrich

W Martin Belef

Ronald J Jabba

Michael T Carley

Charles S Taylor

Ivan Sepetka

Javier Sagastegui

Federico J Benetti

Dwight P Morejohn

Eugene Edward Reis

Stephen M Salmon

William Friederich Witt

Brent Ford Regan

Daniel T Wallace

Anthony J Pantages

Robert LaDuca

Scott Hyler Heneveld

Brandon Gregory Walsh

David C Forster

Amr Salahieh

Thomas J Fogarty

John J Frantzen

Thomas J Palermo

Yue-Teh Jang

Gary B Weller

Valavanur A Subramanian

Benjamin Sherman

Robert C Glines

Hani Shennib

Brian J Bennett

Christian Skieller

Harry L Green

Michael J Billig

Thomas L Baughman

Steven Nelson Roe

David Allan White

William Martin Belef

Matthew Thompson

Ted Richardson

Mike Hooven

Hiram Chee

Michael D Hooven

Darin Charles Gittings

Dean F Carson

Harry Leonard Green, Ii

Richard M Ferrari

Jack W Lasersohn

Francisco Javier Sagastegui

John R McKenzie

Peter Thornton

Phil Olsen

Tellis Hartridge

Adam Shively

Janina Sagastegui, Legal Representative

Jodi J Akin

William F Witt

Brent Regan

Javier Sagasteguei

Martin W Belef

This invention relates to apparatus and methods used to seal a vascular puncture site, particularly sites of punctures that are the result of catheterization or other interventional procedures. The sealing device includes a sealing member and a tether. The sealing member occupies a space in an incision, puncture, or other wound and sealing the space that it occupies, to prevent further blood flow. The tether is attached to the sealing member, and provides the user with the ability to withdraw the sealing member if necessary. The sealing device further includes a restraining member associated with the sealing member. The restraining member provides the ability to more securely restrain the sealing member to prevent it from migrating from the deployment location within a tissue tract. The restraining member also provides an additional capability of manipulating the sealing member after deployment.

Vascular plug having composite construction

An apparatus for sealing a passage through tissue includes a bioabsorbable body disposed on a distal end of a handle device. The plug member includes a helical thread on its outer surface and the plug member and handle device include cooperating lumens communicating with a distal port. A sealing member is disposed within the plug member lumen. An obturator is inserted through the lumens until its distal tip extends beyond the plug member, the distal tip including a bleed back port. The plug member is threaded into a passage towards a blood vessel until the bleed back indicator identifies the location of the vessel with respect to the plug member. The plug member is released from the handle device, the handle device and obturator are withdrawn, and the sealing member seals the lumen. The plug member is left within the passage to seal the passage until the tissue heals.

Apparatus and methods for sealing vascular punctures

An apparatus for sealing a passage through tissue communicating with a blood vessel includes a bioabsorbable plug member coupled to the distal end of a carrier member. The plug member includes a lumen extending therethrough that communicates with a lumen extending through the carrier member. A sealing member is disposed in the plug member lumen for sealing the lumen. A guide member is slidable into the lumen such that edges of a groove extending between proximal and distal portions of the guide member engage a wall of the lumen to define a bleed back lumen. The guide member is inserted into the passage until the distal portion enters the vessel. The plug member is advanced over the guide member until the plug member enters the vessel, whereupon blood enters the bleed back lumen to identify the location of the vessel relative to the plug member.

A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

Closure device and methods for making and using them

An apparatus for positioning an introducer sheath includes a sheath having a distal end including first and second ports, the second port being located distally from the first port. An obturator is slidable within the sheath that includes a distal region that sealingly engages an interior surface of the sheath. The obturator includes first and second openings in the distal region that are alignable with the first and second ports in the sheath. A housing is slidable on the exterior of the sheath that releasably holds a closure element. The sheath may be inserted into an incision communicating with a blood vessel, the first and second ports providing backbleed indication of the depth of the insertion of the sheath into the vessel. The housing is actuated to deploy the closure element to engage and close the incision.

Apparatus and methods for positioning a vascular sheath

Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an integrated vascular device having a sheath with a closure component and puncture sealant. The closure component is disposed on and advanceable over the exterior of the sheath and may comprise any of a variety of apparatus suited for closing a vascular puncture. Once the closure component has been actuated to close the puncture, sealant is introduced to seal the puncture. The sheath and closure component are then removed from the patient.

Integrated vascular device with puncture site closure component and sealant and methods of use

Apparatus are provided for use in sealing a vascular puncture site. The invention comprises an integrated vascular device having a sheath with a closure component and puncture sealant. The closure component is disposed on and advanceable over the exterior of the sheath and may comprise any of a variety of apparatus suited for closing a vascular puncture. Once the closure component has been actuated to close the puncture, sealant is introduced to seal the puncture. The sheath and closure component are then removed from the patient.

Integrated vascular device with puncture site closure component and sealant

An apparatus for sealing a passage through tissue includes a plug including external threads, a lumen extending between its proximal and distal ends, and an annular collet slidably disposed within the lumen. The plug is carried on a distal end of a handle device that includes an inner member with a distal end that is slidable axially within the lumen of the body for moving the collet into a reduced cross-sectional region of the lumen, thereby compressing the collet to seal the lumen, and for deploying the plug from the handle device. During use, the plug is delivered into a passage through tissue over a guide wire. Once a desired location is reached, the plug is deployed from the handle device, thereby compressing the collet and sealing the lumen. The guide wire and handle device are removed, leaving the plug to seal the passage.

Plug with collet and apparatus and methods for delivering such plugs

An apparatus for sealing a vascular puncture and for properly locating and deploying a sealing member. The apparatus comprises a lumen which extends from an opening in the distal region of the apparatus to another opening in the proximal region of the apparatus. A sealing member is located at the end of the lumen. When the distal opening is positioned within the blood vessel lumen, blood flows through the distal opening, through the lumen and out of the proximal opening indicating that the sealing member is within the blood vessel lumen. When the sealing member is withdrawn from the vessel lumen, it blocks the blood flow into the distal opening. The sealing member may be further withdrawn a predetermined distance so that no part of the sealing member extends into the blood vessel lumen. The sealing device is then detached from the delivery apparatus to seal the vascular puncture.

Locator and closure device and method of use

Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.

Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use

Prosthetic valves and their component parts are described, as are prosthetic valve delivery devices and methods for their use. The prosthetic valves are particularly adapted for use in percutaneous aortic valve replacement procedures. The delivery devices are particularly adapted for use in minimally invasive surgical procedures.

Prosthetic heart valves, scaffolding structures, and systems and methods for implantation of same

An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.

Apparatus and methods for providing tactile feedback while delivering a closure device

This invention relates to apparatus and methods for use in sealing a vascular puncture site and to apparatus and methods for properly locating and deploying a sealing device. The locating apparatus includes a lumen which extends from an opening in the distal region of the apparatus but located proximally of the sealing device, which lumen extends to another opening in the proximal region of the device. When the distal opening is in communication with blood in a blood vessel, blood flow through the lumen and out of the proximal opening signifies such location to the user. When the sealing device is withdrawn such that the sealing device is deployed such that it blocks the blood flow into the distal port, the user will know the location of the sealing device. In a preferred embodiment, the sealing device is then withdrawn proximally a predetermined distance to assure that no part of the sealing device extends into the blood vessel lumen. The sealing device is then detached from the delivery device.

Locator and delivery device and method of use

An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end. A skin overlies the outer surface of the sheath and the carrier assembly that is separable from the outer surface as the carrier assembly is advanced from the proximal end towards the distal end of the sheath. During use, the distal end of the sheath is inserted into an opening through tissue, e.g., into a puncture communicating with a blood vessel. The carrier assembly is advanced towards the distal end of the sheath, causing the skin to separate from the outer surface of the elongate member, and the clip is deployed from the carrier to seal the opening.

Sheath apparatus and methods for delivering a closure device

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San Jose, CA, United States of America

Richard S Ginn