Senesco Technologies, Inc.

Other

Ortho Diagnostic Systems Inc.

Richard S Dondero

John E Thompson

Catherine Taylor

Herman F Staats

Ernest G Schutt

Karin L Utberg

George B Hovorka

David L Greenwood

Zhenyu Cheng

William P Hansen

Raymond E Meyer

Zhong Sun

The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.

Compositions comprising siRNA and plasmids

The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide. The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.

Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells

Interleukin-1 muteins useful as vaccine adjuvants

A new immunoassay system is provided for the detection of ligands or ligand binding partners in solution in a heterogeneous format. The invention relies upon the detection of back scattered light from an evanescent wave disturbed by the presence of a colloidal gold label brought to the interface by an immunological reaction. The evanescent wave existing at the interface in turn is the result of a totally internally reflected incident light wave. Placement of the detector at a back angle above the critical angle insures a superior signal-to-noise ratio.

Scattered total internal reflectance immunoassay system

Growing community of inventors

Riverdale, NJ, United States of America

Richard S Dondero